In search of a neuronal substrate of the human mind: new concepts from "topological neurochemistry"

Neurochemistry is a powerful discipline of modern neuroscience based on a description of neuronal function in terms of molecular reaction and interaction. This study aims at a neurochemical approach to the "hard" philosophical mind-body problem: the search for the neuronal correlate of consciousness. The scattered pattern of remote areas in the human brain simultaneously busy with the computation of single perceptions has left us with the unanswered questions why, where, and how the neuronal activity gives rise to a unified conscious observation of the outer world in a space inside of the human brain. In this study, conscious perception of temporally and spatially distinct events by an inner observer, the self, is treated as a topological problem demanding for a correlation of the self with a particular orchestration of neuronal or neurochemical activity triggered by action potentials. According to a novel concept of "topological neurochemistry" it is assumed that three features of the human brain are necessary in order to generate consciousness: 1) A network of neurons with dendritic branching structure and re-entry signaling of action potentials. 2)A macromolecular lattice structure as part of the neuron which is excitable or modulated by action potentials. 3) A spatial superposition of action potentials which underlies conscious perception but reveals not necessarily the same topology as the space perceived in consciousness. Several molecular models for the generation of consciousness and the self will be discussed, and a new concept, the "fractal approach", will be introduced. Mathematical theory and experimental methods for investigation of human consciousness will be presented